EPICLIN project


Center of clinical epidemiology for the experimental study in oncology of the CPO Piemonte


The Centre of Clinical Epidemiology for experimental oncological studies sets its goal in supplying methodological support to research groups, through collaboration in setting,conducting and analysing clinical studies, prioritizing on spontaneous studies rather than commercial ones.
With this aim in mind, thanks to the help and funding of Compagnia di San Paolo, in 2003 the design of the website EPICLIN (acronim for "EPIdemiologic CLINic") has been started in order to supply IT instruments useful for managing and collecting data (case report forms, CRFs) of trials.


Realising a web application in order to facilitate data-collection for experimental studies (in substitution of traditional paper files), clinical monitoring and statistic analysis.
The Epiclin website has been created to favour the managing of multicentric studies in the oncological and oncoematological sphere on a national and international scale. Those studies are promoted especially by the Oncological Network of Piedmont and Valle d'Aosta, by the Italian Foundation for Lymphomas and by the Italian Foundation for Myelodysplastic Syndromes.

2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
Aree 1 4 6 7 13 16 20 24 28 33 35 36 40 50 51
Adesioni 11 33 68 138 235 357 469 599 753 819 883 933 978 1022 1027
Pazienti nei Trials 30 137 299 545 801 1695 2355 3134 3819 4430 5634 7122 8457 9943 10013
Pazienti in MDS Registro 909 1036 1187 1294 1438 1616 1933 2416 3017 3563 4032 4380 4620 4798 4811
Pazienti in Registro LMC GIMEMA 0 0 0 0 1 1 1 1 9 40 97 478 1182 1642 1659

Each area corresponds to a clinical study enrollment phase, follow-up or analysis.
The active centers, through specific subscriptions, can participate in multiple areas. The MDS register has been acquired since 2008.


The web site has been developed within the Organisation by a team of computer scientists, a team coordinated by epidemiologists and experimenters of trials. Through a modular structure that guarantees the flexibility of the data-entry system, many different areas of access have been implemented, which are reserved only for authorised users and respecting all measures of security and privacy.( D.Lgs. 196/2003)

Guaranteed features:

  • Continuous maintenance of the application and operativity of the host
  • Admin server and assistance towards the web site users
  • Security of informations implemented through a frequent data backup

In all areas there are:

  • Procedures of enrollment of patients and assignment of identification codes
  • Automation and control of randomising operations
  • Management centralisation of medical reports on behalf of medical laboratories
  • Real time registration of negative events and toxicity during therapy
  • Website interface also developed in English


The EPICLIN website, online since May 2004, allows to collect data through the web in association with or replacing the traditional paper cards. To day there are 51 active work areas, related to 49 clinical trials (phase II and phase III studies) and 2 regional registry database (MDS Registro, Registro LMC GIMEMA). 402 hospitals operate in these areas with 1038 subscriptions.
The uninterrupted, real-time data collection allows to evaluate the activity carried out by each centre, with a focus on completeness and formal correctness of collected data.


The data collection via web represents an organisational support appreciated by clinicians, with an increasement of collaborations with the Centre of Clinical Epidemiology through the years. Furthermore, the development of Epiclin carried out by human resources within the Centre allows experimenters a high flexibility in usage and a constant collaboration towards the development of different areas.


Regular mail

  • SC Epidemiologia dei Tumori - CPO U
    AOU Città della Salute e della Scienza di Torino - PO Molinette
    Progetto EPICLIN
    Via Santena 7
    10126 Torino TO

Email, phone and fax